Diabetes and obesity are central acquired metabolic conditions affecting millions of people worldwide. Metabolic imaging and pharmacologic, genetic or dietary manipulation of metabolism increase our understanding of the complex metabolic interactions. This research profile reaches from clinical studies and patient care to transcriptomics and radiomics in a sense of reverse translation.
Jochen Seufert 
Faculty of Medicine and Medical Center – Department of Medicine II (Endocrinology and Diabetology)
RESEARCH: Glucose Metabolism, Endocrine Pancreas Regeneration and Signal Transduction, Stem Cell Biology, Adipose Tissue Biology, Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes, Obesity, Incretin Hormones, Clinical Trials in Diabetes and Metabolism, Novel Diabetes Medications, Insulin Research, Cardiovascular Disease, Inflammation, NAFLD
METHODS: Cell Biology, Animal Models for Obesity and Diabetes, Pharmacologic and Genetic Manipulation of Metabolism, Clinical Trials in Patients, Endoscopic bariatric interventions
TECHNOLOGIES: Clinical Trial Unit, Phase I-IV, Glucose Clamps in Animals and Humans
Clinical Trials: EFFORT, SCORED, COMBAT-T2-NASH
Dennis Wolf
Faculty of Medicine and Medical Center – Cardiology and Angiology I, Vascular Immunology Laboratory
RESEARCH: Acquired Metabolic Disease, Metabolic Signalling, Immunometabolism, Adaptive Immunity, T cells, Signal Transduction, Cell Biology, Inflammatory Diseases, Cardiovascular Diseases, Apolipoproteins, Autoimmunity
METHODS: Flow Cytometry, CyTOF, single cell RNA-sequencing, clinical studies, Pharmacologic and genetic manipulation of metabolism, Transcriptomics
TECHNOLOGY: Comprehensive Lab Animal Monitoring System (CLAMS)
Johanna Nattenmüller
Faculty of Medicine and Medical Center – Department of Radiology
RESEARCH: Metabolic Imaging, visualization and quantification of adipose tissue and muscle distribution/body composition, link between obesity & cancer, sarcopenia, sarkopenic obesity, obesity paradox, imaging in population-based cohorts and dietary intervention trials
METHODS: Quantification of adipose tissue (visceral & subcutaneous adipose tissue, fat deposits in liver, pancreas, kidney, bone marrow & muscle tissue) with cross-sectional imaging techniques: computed tomography (CT) and magnetic resonance imaging (MRI)
TECHNOLOGIES: CT and MRI scanner with post-processing software for image analysis
