The two teams discovered a mega-protein complex with surprising properties in mitochondria!

The team unveiled a new mechanism for regulating mitochondrial function. The findings demonstrate the critical role of the lysine acetyltransferase MOF in maintaining mitochondrial integrity and function through acetylation of mitochondrial electron transport chain component COX17.

Using biochemical and cell-biology experiments, the team demonstrated for the first time precisely how mitochondrial proteins with signal sequences are imported into the mitochondria via a negatively charged, unique groove.